{"id":97,"date":"2024-04-12T17:07:30","date_gmt":"2024-04-12T08:07:30","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/?page_id=97"},"modified":"2024-04-17T16:52:51","modified_gmt":"2024-04-17T07:52:51","slug":"achievements","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/achievements.html","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"\r\n<p><strong>2024\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jphs.2023.12.010\">Mechanism of cytotoxicity induced by the cigarette smoke extract (CSE) of heated tobacco products in vascular smooth muscle cells: A comparative study of the cytotoxic effects of CSE and the ferroptosis inducer, erastin<\/a>. Takahiro Horinouchi, Yuichi Mazaki, Soichi Miwa <em>Journal of Pharmacological Sciences<\/em>\u00a0154\u00a086 &#8211; 96<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p><strong>2023\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1186\/s12964-023-01305-y\">LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity.<\/a> Yuichi Mazaki, Haruka Handa, Yoshizuki Fumoto, Takahiro Horinouchi, Yasuhito Onodera <em>Cell communication and signaling<\/em> : CCS\u00a021\u00a01\u00a0300 &#8211; 300<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jphs.2023.06.001\">Protein kinase C\u03b2 is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages<\/a>. Tsunehito Higashi, Haruka Handa, Yosuke Mai, Katsumi Maenaka, Takashi Tadokoro <em>Journal of Pharmacological Sciences<\/em>\u00a0153\u00a01\u00a022 &#8211; 25<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p><strong>2022\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.toxrep.2022.06.001\">Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells.<\/a> Hirata N, Horinouchi T, Kanda Y <em>Toxicology Reports<\/em>\u00a09\u00a01273 &#8211; 1280<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p><strong>2021\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.ajpath.2020.10.004\">Decreased proteasomal function induces neuronal loss and memory impairment<\/a>. Tomaru U, Ito T, Ohmura Y, Higashikawa K, Miyajima S, Tomatsu R, Higashi T, Ishizu A, Kuge Y, Yoshioka M, Kasahara M <em>Am J Pathol<\/em>\u00a0191\u00a01\u00a0144 &#8211; 156<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jphs.2021.07.005\">Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells<\/a>. Takahiro Horinouchi, Soichi Miwa <em>Journal of Pharmacological Sciences<\/em>\u00a0147\u00a0223 &#8211; 233<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p><strong>2020\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1038\/s41598-020-77582-1\">Fibrinolysis-resistant carbonylated fibrin detected in thrombi attached to the vascular wall of abdominal aortic aneurysms.<\/a> Yuko Suzuki, Hiroki Tanaka, Takahiro Horinouchi, Hideto Sano, Naoki Honkura, Naoki Unno, Soichi Miwa, Tetsumei Urano <em>Scientific reports<\/em>\u00a010\u00a01\u00a020728 &#8211; 20728<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1248\/bpb.b20-00522\">Cigarette Smoke Extract and Its Cytotoxic Factor Acrolein Inhibit Nitric Oxide Production in Human Vascular Endothelial Cells.<\/a> Takahiro Horinouchi, Yuichi Mazaki, Koji Terada, Soichi Miwa <em>Biological &amp; pharmaceutical bulletin<\/em>\u00a043\u00a011\u00a01804 &#8211; 1809<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jphs.2019.06.009\">Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-Gq\/11 protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells.<\/a> Takahiro Horinouchi, Yuichi Mazaki, Koji Terada, Soichi Miwa <em>Journal of pharmacological sciences<\/em>\u00a0143\u00a04\u00a0315 &#8211; 319<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1152\/ajpheart.00559.2019\">Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells<\/a>. Sampilvanjil A, Karasawa T, Yamada N, Komada T, Higashi T, Baatarjav C, Watanabe S, Kamata R, Ohno N, Takahashi M <em>Am J Physiol Heart Circ Physiol<\/em>\u00a0318\u00a03\u00a0H508 &#8211; H518<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p><strong>2019\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.bmc.2019.115149\">Pyrenosine A induces monopolar spindle formation and suppress proliferation of cancer cells<\/a>. Myobatake Y, Kamisuki S, Tsukuda S, Higashi T, Chinen T, Takemoto K, Hachisuka M, Suzuki Y, Takei M, Tsurukawa Y, Maekawa H, Takeuchi T, Matsunaga TM, Sahara H, Usui T, Matsunaga S, Sugawara F <em>Bioorg Med Chem<\/em>\u00a027\u00a023\u00a0115149 &#8211; 115149<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.bbrc.2019.04.037\">Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells<\/a>. Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H <em>Biochem Biophys Res Commun<\/em>\u00a0513\u00a03\u00a0708 &#8211; 713<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jphs.2019.03.008\">Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells.<\/a> Takahiro Horinouchi, Sarita Karki, Koji Terada, Yuichi Mazaki, Soichi Miwa <em>Journal of pharmacological sciences<\/em>\u00a0140\u00a01\u00a0102 &#8211; 105<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.bbrc.2019.02.040\">Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation.<\/a> Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa <em>Biochemical and biophysical research communications<\/em>\u00a0511\u00a01\u00a069 &#8211; 72<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1002\/1873-3468.13347\">Endothelin type B receptor interacts with the 78-kDa glucose-regulated protein.<\/a> Yuichi Mazaki, Tsunehito Higashi, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Shigeru Hashimoto, Takahiro Horinouchi, Soichi Miwa <em>FEBS letters\u00a0<\/em>593\u00a06\u00a0644 &#8211; 651<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.bbrc.2019.01.040\">Glutathione and cysteines suppress cytotoxicity of gas phase of cigarette smoke by direct reacting with unsaturated carbonyl compounds in the gas phase.<\/a> Tsunehito Higashi, Enas Elmeligy, Yosuke Mai, Yoichi Noya, Koji Terada, Yuichi Mazaki, Yuji Kuge, Soichi Miwa <em>Biochemical and biophysical research communications<\/em>\u00a0509\u00a04\u00a0988 &#8211; 993<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.rmcr.2019.02.007\">Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis: A case report and experimental investigation.<\/a> Kazuki Sato, Hiroshi Ohira, Takahiro Horinouchi, Toshitaka Nakaya, Yuichi Mazaki, Ayako Sugimoto, Taku Watanabe, Ichizo Tsujino, Masaharu Nishimura <em>Respiratory medicine case reports<\/em>\u00a026\u00a0265 &#8211; 269<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1111\/bjd.17121\">Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen-antibody reaction time for detection<\/a>. Mai Y, Ujiie H, Higashi T, Yamagami J, Iwata H, Shimizu H <em>Br J Dermatol<\/em>\u00a0180\u00a01\u00a0215 &#8211; 216<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p><strong>2018\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jbiosc.2018.04.020\">Protein kinase C-dependent cell damage by unsaturated carbonyl compounds in vascular cells<\/a>. Tsunehito Higashi, Yosuke Mai, Yuichi Mazaki <em>Journal of Bioscience and Bioengineering<\/em>\u00a0126\u00a04\u00a0527 &#8211; 532\u00a0<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p><strong>2017\u5e74<\/strong><\/p>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jbiosc.2017.07.003\">Intracellular Ca2+ is an essential factor for cell damage induced by unsaturated carbonyl compounds<\/a>. Tsunehito Higashi, Yosuke Mai, Yuichi Mazaki, Soichi Miwa <em>JOURNAL OF BIOSCIENCE AND BIOENGINEERING<\/em>\u00a0124\u00a06\u00a0680 &#8211; 684<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1186\/s12964-017-0193-y\">ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis<\/a>. Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa, Hisataka Sabe <em>CELL COMMUNICATION AND SIGNALING<\/em>\u00a015\u00a036<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1055\/s-0037-1607979\">Cigarette smoke extract inhibits platelet aggregation by suppressing cyclooxygenase activity<\/a> Kashiwagi H, Yuhki K, Imamichi Y, Kojima F, Kumei S, Higashi T, Horinouchi T, Miwa S, Narumiya S, Ushikubi F <em>TH Open<\/em>\u00a01\u00a02\u00a0e122 &#8211; e129<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<ul>\r\n<li><a href=\"http:\/\/dx.doi.org\/10.1055\/s-0037-1607979\">Cigarette Smoke Extract Inhibits Platelet Aggregation by Suppressing Cyclooxygenase Activity.<\/a> Hitoshi Kashiwagi, Koh-Ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa, Shuh Narumiya, Fumitaka Ushikubi <em>TH open<\/em> : companion journal to thrombosis and haemostasis\u00a01\u00a02\u00a0e122-e129 &#8211; e129<\/li>\r\n<\/ul>\r\n","protected":false},"excerpt":{"rendered":"<p>2024\u5e74 2023\u5e74 2022\u5e74 20 &hellip; <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/pages\/97"}],"collection":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/comments?post=97"}],"version-history":[{"count":58,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/pages\/97\/revisions"}],"predecessor-version":[{"id":299,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/pages\/97\/revisions\/299"}],"wp:attachment":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-json\/wp\/v2\/media?parent=97"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}