{"id":32,"date":"2024-04-12T17:07:37","date_gmt":"2024-04-12T08:07:37","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/?page_id=32"},"modified":"2024-04-30T17:01:13","modified_gmt":"2024-04-30T08:01:13","slug":"research","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/research.html","title":{"rendered":"\u7814\u7a76\u6982\u8981"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p style=\"font-size:25px\"><strong>\uff08\uff11\uff09\u305f\u3070\u3053\u30cf\u30fc\u30e0\u30ea\u30c0\u30af\u30b7\u30e7\u30f3\u306b\u304a\u3051\u308b\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u306e\u610f\u7fa9\u306e\u79d1\u5b66\u7684\u691c\u8a3c\uff1a\u305f\u3070\u3053\u7159\u6210\u5206\u304c\u751f\u4f53\u53ca\u3073\u7d30\u80de\u6a5f\u80fd\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306e\u89e3\u6790<\/strong><\/p>\n\n\n\n<p>\u3000\u305f\u3070\u3053\u30cf\u30fc\u30e0\u30ea\u30c0\u30af\u30b7\u30e7\u30f3\u3068\u306f\uff0c\u305f\u3070\u3053 (\u55ab\u7159) \u306e\u5bb3\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\uff0c\u55ab\u7159\u95a2\u9023\u75be\u60a3\u306b\u3088\u308b\u4eba\u9593\u3084\u793e\u4f1a\u3078\u306e\u8ca0\u8377\u3092\u8efd\u6e1b\u3059\u308b\u6982\u5ff5\u3067\u3042\u308b\u3002\u672c\u90a6\u3067\u306f\uff0c\u305f\u3070\u3053\u30cf\u30fc\u30e0\u30ea\u30c0\u30af\u30b7\u30e7\u30f3\u3092\u76ee\u7684\u3068\u3057\u3066\uff0c\u30cb\u30b3\u30c1\u30f3\u30ac\u30e0\u3084\u30d1\u30c3\u30c1\u306a\u3069\u306e\u30cb\u30b3\u30c1\u30f3\u7f6e\u63db\u7642\u6cd5\u306e\u85ac\u5264\u3084\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u88fd\u54c1\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u8fd1\u5e74\uff0c\u55ab\u7159\u8005\u306e\u5065\u5eb7\u5fd7\u5411\u306e\u9ad8\u307e\u308a\u3084\u6539\u6b63\u5065\u5eb7\u5897\u9032\u6cd5\u306e\u65bd\u884c\u3092\u53d7\u3051\u3066\uff0c\u7d19\u5dfb\u305f\u3070\u3053\u306e\u55ab\u7159\u304b\u3089\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u88fd\u54c1\u306e\u4f7f\u7528\u3078\u3068\uff0c\u55ab\u7159\u8005\u306e\u884c\u52d5\u5909\u5bb9\u304c\u9032\u3093\u3067\u3044\u308b\u3002\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u306e\u55ab\u7159\u3067\u306f\uff0c\u71c3\u713c\u306b\u3088\u308b\u5316\u5b66\u7269\u8cea\u306e\u767a\u751f\u3092\u4f34\u308f\u306a\u3044\u3053\u3068\u304b\u3089\uff0c\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u306e\u4e3b\u6d41\u7159\u306b\u542b\u307e\u308c\u308b\u5316\u5b66\u7269\u8cea\u306e\u91cf\u306f\uff0c\u7d19\u5dfb\u305f\u3070\u3053\u3088\u308a\u3082\u5c11\u306a\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u305d\u308c\u6545\uff0c\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u306f\uff0c\u55ab\u7159\u306b\u4f34\u3046\u5316\u5b66\u7269\u8cea\u306e\u66dd\u9732\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b\u88fd\u54c1\u3068\u3057\u3066\uff0c\u65e5\u672c\u56fd\u5185\u5916\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u3002\u4e00\u65b9\uff0c\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u306e\u4e3b\u6d41\u7159\u4e2d\u306b\u3082\uff0c\u7d19\u5dfb\u305f\u3070\u3053\u3068\u540c\u69d8\u306b\uff0c\u30cb\u30b3\u30c1\u30f3\u3084\u30a2\u30af\u30ed\u30ec\u30a4\u30f3\u3068\u3044\u3063\u305f\u751f\u4f53\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u5065\u5eb7\u61f8\u5ff5\u7269\u8cea\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\uff0c\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u55ab\u7159\u8005\u306e\u5065\u5eb7\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u79d1\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u5727\u5012\u7684\u306b\u5c11\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u5f53\u6559\u5ba4\u3067\u306f\uff0c\u52a0\u71b1\u5f0f\u305f\u3070\u3053\u3068\u7d19\u5dfb\u305f\u3070\u3053\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u79d1\u5b66\u7684\u306b\u691c\u8a3c\u3059\u308b\u305f\u3081\uff0c\u305f\u3070\u3053\u4e3b\u6d41\u7159\u66dd\u9732\u52d5\u7269\u3092\u4f5c\u88fd\u3057\uff0c\u547c\u5438\u5668\u306b\u5bfe\u3059\u308b\u55ab\u7159\u306e\u5f71\u97ff\u3092\u907a\u4f1d\u5b50\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u30fb\u7d44\u7e54\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3057\u3066\u3044\u308b\u3002\u307e\u305f\uff0c\u69d8\u3005\u306a\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066\uff0c\u305f\u3070\u3053\u7159\u6210\u5206\u304c\u7d30\u80de\u6a5f\u80fd\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u89e3\u6790\u3057\uff0c\u5065\u5eb7\u61f8\u5ff5\u7269\u8cea\u306e\u540c\u5b9a\u3068\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p style=\"font-size:25px\"><strong>\uff08\uff12\uff09\u597d\u4e2d\u7403\u306e\u6d3b\u6027\u5316\u53ca\u3073\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76<\/strong><\/p>\n\n\n\n<p>\u3000\u597d\u4e2d\u7403\u306f\u3001\u30d2\u30c8\u306e\u767d\u8840\u7403\u306e\u534a\u6570\u4ee5\u4e0a\u3092\u5360\u3081\u308b\u91cd\u8981\u306a\u514d\u75ab\u7d30\u80de\u3067\u3042\u308a\u3001\u305d\u306e\u4e3b\u306a\u5f79\u5272\u306f\u3001\u4f53\u5185\u306b\u4fb5\u5165\u3057\u3066\u304d\u305f\u75c5\u539f\u4f53\u3092\u8caa\u98df\u3057\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306b\u3088\u308a\u4e0d\u6d3b\u5316\u3057\u3001\u4f53\u5185\u304b\u3089\u6392\u9664\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u307e\u305f\u3001\u8fd1\u5e74\u3001\u597d\u4e2d\u7403\u306f\u81ea\u3089\u306e\u6838\u5185\u306e\u30af\u30ed\u30de\u30c1\u30f3\u3092\u653e\u51fa\u3057\u3001\u75c5\u539f\u4f53\u3092\u6349\u3048\u308bneutrophil extracellular traps (NETs)\u306b\u3088\u3063\u3066\u3082\u3001\u75c5\u539f\u4f53\u3092\u6392\u9664\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u597d\u4e2d\u7403\u306e\u4e3b\u306a\u50cd\u304d\u306f\u3001\u75c5\u539f\u4f53\u3092\u4f53\u5185\u304b\u3089\u6392\u9664\u3059\u308b\u3053\u3068\u3067\u3042\u308a\u3001\u597d\u4e2d\u7403\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u611f\u67d3\u75c7\u306b\u7f79\u308a\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u306f\u3001\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u60a3\u8005\u3067\u898b\u3089\u308c\u308b\u3088\u3046\u306b\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u597d\u4e2d\u7403\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u8d77\u3053\u308bROS\u306b\u3088\u308b\u7d44\u7e54\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u3084NETs\u306b\u3088\u308b\u5168\u8eab\u3067\u306e\u8840\u6813\u306a\u3069\u306b\u3088\u3063\u3066\u3001\u6b7b\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u904e\u5270\u306a\u597d\u4e2d\u7403\u306e\u53cd\u5fdc\u3092\u6291\u3048\u308b\u85ac\u3068\u3057\u3066\u3001\u73fe\u5728\u3001\u6700\u3082\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u85ac\u304c\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\u85ac\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u9aa8\u7c97\u9b06\u75c7\u3084\u9ad8\u8840\u7cd6\u75c7\u3092\u306f\u3058\u3081\u3001\u69d8\u3005\u306a\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u304c\u6b20\u70b9\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u539f\u56e0\u3068\u3057\u3066\u3001\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\u85ac\u304c\u3001\u514d\u75ab\u7d30\u80de\u4ee5\u5916\u306e\u69d8\u3005\u306a\u7d30\u80de\u3084\u7d44\u7e54\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u597d\u4e2d\u7403\u306e\u6d3b\u6027\u5316\u3092\u6291\u3048\u308b\u305f\u3081\u306b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u4f5c\u7528\u3059\u308b\u6297\u4f53\u533b\u85ac\u3082\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u73fe\u5728\u306e\u3068\u3053\u308d\u3001\u5b8c\u5168\u306b\u708e\u75c7\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3000\u79c1\u305f\u3061\u306f\u3001\u597d\u4e2d\u7403\u306e\u6d3b\u6027\u5316\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u878d\u5408\u306b\u95a2\u4fc2\u3059\u308bMitofusin 2\uff08MNF2\uff09\u3084Leucine Rich Repeat Kinase 2\uff08LRRK2\uff09\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000\u597d\u4e2d\u7403\u306e\u6d3b\u6027\u5316\u53ca\u3073\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u6d3b\u6027\u5316\u3059\u308b\u597d\u4e2d\u7403\u306e\u50cd\u304d\u3092\u76f4\u63a5\u6291\u3048\u3001\u4ed6\u306e\u7d44\u7e54\u3084\u7d30\u80de\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u306a\u304f\u5236\u5fa1\u3067\u304d\u308b\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u85ac\u5264\u3092\u958b\u767a\u306b\u8ca2\u732e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:30% auto\"><figure class=\"wp-block-media-text__media\"><video controls src=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/cellularpharm.med\/Root\/wp-content\/uploads\/2024\/04\/Movie-S1.mov\"><\/video><\/figure><div class=\"wp-block-media-text__content\">\n<p><strong>\u30de\u30a4\u30af\u30ed\u30b7\u30ea\u30f3\u30b8\u306e\u5148\u304b\u3089\u653e\u51fa\u3055\u308c\u3066\u3044\u308b\u7d30\u83cc\u6027\u30da\u30d7\u30c1\u30c9 <em>N<\/em>-formyl-Met-Leu-Phe\uff08<em>f<\/em>MLP\uff09\u306b\u5411\u304b\u3063\u3066\u52d5\u304f\u597d\u4e2d\u7403\u69d8\u7d30\u80de<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p style=\"font-size:25px\"><strong>\uff08\uff13\uff09\u74b0\u5883\u5316\u5b66\u7269\u8cea\u306e\u6bd2\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u305d\u306e\u75c5\u614b\u751f\u7406\u4f5c\u7528\u306e\u89e3\u660e<\/strong><\/p>\n\n\n\n<p>\u3000\u6211\u3005\u306f\u3001\u69d8\u3005\u306a\u5316\u5b66\u7269\u8cea\u306b\u56f2\u307e\u308c\u3066\u751f\u6d3b\u3057\u3066\u3044\u307e\u3059\u3002\u5316\u5b66\u7269\u8cea\u306e\u4e2d\u306b\u306f\u3001\u6211\u3005\u306e\u4f53\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3082\u306e\u3082\u6570\u591a\u304f\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u306b\u30bf\u30d0\u30b3\u306e\u7159\u304c\u3042\u308a\u307e\u3059\u3002\u30bf\u30d0\u30b3\u306e\u7159\u306f4,000\u7a2e\u985e\u4ee5\u4e0a\u306e\u5316\u5b66\u7269\u8cea\u304b\u3089\u6210\u308b\u6df7\u5408\u7269\u3067\u3059\u304c\u3001\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u305d\u308c\u3089\u306e\u5316\u5b66\u7269\u8cea\u306e\u4e2d\u304b\u3089\u300c\u7d30\u80de\u3092\u6bba\u3059\u4f5c\u7528\u304c\u975e\u5e38\u306b\u5f37\u3044\u5316\u5408\u7269\u7fa4\u300d\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\uff08Noya et al., 2013; Higashi et al., 2014\uff09\u3002\u305d\u308c\u3089\u306e\u5316\u5408\u7269\u306e\u4e2d\u306b\u300c\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u300d\u306b\u5206\u985e\u3055\u308c\u308b\u30a2\u30af\u30ed\u30ec\u30a4\u30f3\uff08acrolein\uff09\u3068\u30e1\u30c1\u30eb\u30d3\u30cb\u30eb\u30b1\u30c8\u30f3\uff08methyl vinyl ketone\uff09\u304c\u3042\u308a\u307e\u3059\u3002<br>\u3000\u30a2\u30af\u30ed\u30ec\u30a4\u30f3\u3084\u30e1\u30c1\u30eb\u30d3\u30cb\u30eb\u30b1\u30c8\u30f3\u306f\u3001\u30bf\u30d0\u30b3\u306e\u7159\u306b\u542b\u307e\u308c\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u8349\u6728\u3084\u6cb9\u8102\u985e\u306a\u3069\u306e\u6709\u6a5f\u5316\u5408\u7269\u3092\u71c3\u713c\u3055\u305b\u305f\u969b\u306b\u767a\u751f\u3059\u308b\u7159\u3084\u81ea\u52d5\u8eca\u306e\u6392\u6c17\u30ac\u30b9\u306b\u542b\u307e\u308c\u308b\u307b\u304b\u3001\u3042\u308b\u7a2e\u306e\u6297\u304c\u3093\u85ac\u306e\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u3063\u305f\u308a\u3001\u5225\u306e\u5316\u5408\u7269\u306e\u6709\u6a5f\u5408\u6210\u306b\u3082\u4f7f\u308f\u308c\u308b\u306a\u3069\u3001\u6211\u3005\u306e\u74b0\u5883\u306b\u5b58\u5728\u3059\u308b\u74b0\u5883\u6bd2\u6027\u7269\u8cea\u306e\u4e00\u3064\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u306b\u6211\u3005\u304c\u66dd\u9732\u3055\u308c\u308b\u3068\u3001\u6211\u3005\u306e\u4f53\u306e\u4e2d\u306b\u3042\u308b\u7d30\u80de\u306e\u50cd\u304d\u306b\u7570\u5e38\u304c\u8d77\u3053\u3063\u305f\u308a\u7d30\u80de\u304c\u6b7b\u3093\u3067\u3057\u307e\u3063\u305f\u308a\u3057\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u3001\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u7d30\u80de\u306b\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u308a\u7d30\u80de\u3092\u6bba\u3057\u305f\u308a\u3059\u308b\u304b\u306f\u3001\u3053\u308c\u307e\u3067\u6b86\u3069\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6211\u3005\u306e\u7814\u7a76\u5ba4\u306f\u3001\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u306e\u6bd2\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u9032\u3081\u3001\u3053\u308c\u307e\u3067\u306b\uff11\uff09\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u304c\u69d8\u3005\u306a\u7d30\u80de\u7cfb\u306b\u304a\u3044\u3066\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcC\uff08PKC\uff09\u4f9d\u5b58\u7684\u306b\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\uff08Noya et al., 2013; Higashi et al., 2018\uff09\u3001\uff12\uff09\u305d\u306e\u7d30\u80de\u6b7b\u304c\u300c\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u300d\u3068\u547c\u3070\u308c\u308b\u7a2e\u985e\u3067\u3042\u308b\u3053\u3068\uff08Higashi et al., 2023; Horinouchi et al., 2014\uff09\u3001\u306a\u3069\u3092\u767a\u898b\u3057\u3066\u304d\u307e\u3057\u305f\u3002<br>\u3000\u3053\u308c\u3089\u306e\u7814\u7a76\u6210\u679c\u3092\u3055\u3089\u306b\u767a\u5c55\u3055\u305b\u308b\u305f\u3081\u3001\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u306b\u3088\u308b\u7d30\u80de\u6b7b\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3088\u308a\u8a73\u7d30\u306b\u8abf\u3079\u308b\u3068\u5171\u306b\u3001\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u5316\u5408\u7269\u304c\u7d30\u80de\u6b7b\u4ee5\u5916\u306b\u7d30\u80de\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3001\u307e\u305f\u305d\u308c\u304c\u6211\u3005\u306e\u4f53\u306b\u3069\u306e\u3088\u3046\u306a\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u304b\u3001\u3068\u3044\u3046\u3053\u3068\u306a\u3069\u3092\u660e\u3089\u304b\u306b\u3057\u3088\u3046\u3068\u8a66\u307f\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff08\uff11\uff09\u305f\u3070\u3053\u30cf\u30fc\u30e0\u30ea\u30c0\u30af\u30b7\u30e7\u30f3\u306b\u304a\u3051\u308b\u52a0 &hellip; 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